Follistatin is a monomeric glycoprotein that binds and neutralizes activin; FS315, its full-length isoform, carries an acidic C-terminal tail that the shorter FS288 lacks, the two arising from alternatively spliced messenger RNAs.
emerging — human data exists, and it is thin or contested
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
created page created as 'Follistatin-315 (FST-315)' with aliases FST-315, Follistatin 315, circulating follistatin isoform · 2026-09-27 12:04 · somebody
kind set kind set to protein: palette r2 · 2026-09-27 12:04 · somebody
identity withheld identity not published: PubChem gave no record that proves it is this substance · 2026-09-27 12:04 · somebody
fact added summary: Follistatin is a monomeric glycoprotein that binds and neutralizes activin; FS315, its full-length isoform, carries an a · 2026-09-27 12:04 · somebody
fact added mechanism: Recombinant human FS315 suppressed FSH release from rat pituitary cells about as potently as native follistatin, whereas · 2026-09-27 12:04 · somebody
fact added summary: An FS315-specific immunoassay showed FS315 to be the main follistatin isoform circulating in human serum, while it was u · 2026-09-27 12:04 · somebody
citation added pmid 15472207 cited as emerging: FS315 is the major circulating follistatin isoform in human serum; isoforms are distributed by their · 2026-09-27 12:04 · somebody
citation added pmid 1906804 cited as preclinical: Recombinant FS315 and FS288 differ in potency at suppressing pituitary FSH release · 2026-09-27 12:04 · somebody
Negative findings
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