Follistatin is a monomeric glycoprotein that binds and neutralizes activin; FS315, its full-length isoform, carries an acidic C-terminal tail that the shorter FS288 lacks, the two arising from alternatively spliced messenger RNAs.
emerging — human data exists, and it is thin or contested
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Follistatin is a monomeric glycoprotein that binds and neutralizes activin; FS315, its full-length isoform, carries an acidic C-terminal tail that the shorter FS288 lacks, the two arising from alternatively spliced messenger RNAs. · pmid:15472207
An FS315-specific immunoassay showed FS315 to be the main follistatin isoform circulating in human serum, while it was undetectable in ovarian follicular fluid. · pmid:15472207
Mechanism
Recombinant human FS315 suppressed FSH release from rat pituitary cells about as potently as native follistatin, whereas recombinant FS288 was 8 to 10 times more potent. · pmid:1906804
Identity
No public registry record is shown for this page: PubChem gave no record that proves it is this substance.
Where the evidence actually sits
Emerging50%
Preclinical only50%
Proportion of the 2 claims about Follistatin-315 (FST-315) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Follistatin-315 (FST-315) yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
Differential distribution of follistatin isoforms: application of a new FS315-specific immunoassay. · pmid 15472207 · 2004
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Recombinant expression of human follistatin with 315 and 288 amino acids: chemical and biological comparison with native porcine follistatin. · pmid 1906804 · 1991
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.