Peptide Atlas · Protein

Follistatin-315 (FST-315)

Follistatin is a monomeric glycoprotein that binds and neutralizes activin; FS315, its full-length isoform, carries an acidic C-terminal tail that the shorter FS288 lacks, the two arising from alternatively spliced messenger RNAs.

emerging

provisional
2 citations
0 discussions
0 followers
FST-315
Follistatin 315
circulating follistatin isoform

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What the evidence says

six tiers, never blended

emerging — human data exists, and it is thin or contested

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Follistatin-315 (FST-315). Tier reflects study design, not enthusiasm.
Claim	Tier	Source
FS315 is the major circulating follistatin isoform in human serum; isoforms are distributed by their proteoglycan binding	emerging	pmid 15472207
Recombinant FS315 and FS288 differ in potency at suppressing pituitary FSH release	preclinical	pmid 1906804

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.