Peptide Atlas · Protein

Follistatin-315 (FST-315)

Follistatin is a monomeric glycoprotein that binds and neutralizes activin; FS315, its full-length isoform, carries an acidic C-terminal tail that the shorter FS288 lacks, the two arising from alternatively spliced messenger RNAs.

emerging

provisional
2 citations
0 discussions
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FST-315
Follistatin 315
circulating follistatin isoform

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What the evidence says

six tiers, never blended

emerging — human data exists, and it is thin or contested

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- emerging
  Claim: FS315 is the major circulating follistatin isoform in human serum; isoforms are distributed by their proteoglycan binding standing
- resolved
Differential distribution of follistatin isoforms: application of a new FS315-specific immunoassay.
Schneyer AL, Wang Q, Sidis Y, Sluss PM
pmid 15472207
- preclinical
  Claim: Recombinant FS315 and FS288 differ in potency at suppressing pituitary FSH release standing
- resolved
Recombinant expression of human follistatin with 315 and 288 amino acids: chemical and biological comparison with native porcine follistatin.
Inouye S, Guo Y, DePaolo L, Shimonaka M, Ling N, Shimasaki S
pmid 1906804

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Negative findings

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