Humanin is an anti-apoptotic peptide of 24 amino acids; an identical open reading frame exists in the mitochondrial genome, and the mitochondrial version also binds and suppresses the cell-death protein Bax.
fact added identity: CAS registry number 330936-69-1. · 2026-09-27 04:00 · somebody
fact added summary: Humanin is an anti-apoptotic peptide of 24 amino acids; an identical open reading frame exists in the mitochondrial geno · 2026-09-27 04:00 · somebody
fact added mechanism: It prevents Bax from moving from the cytosol to mitochondria and suppresses cytochrome c release. · 2026-09-27 04:00 · somebody
fact added classification: It is described as the first small peptide of a putative set of mitochondrial-derived peptides, with strong cytoprotecti · 2026-09-27 04:00 · somebody
citation added pmid 12732850 cited as preclinical: Humanin suppresses apoptosis by interfering with Bax activation · 2026-09-27 04:00 · somebody
citation added pmid 23402768 cited as preclinical: Humanin as the first mitochondrial-derived peptide · 2026-09-27 04:00 · somebody
Negative findings
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