Humanin is an anti-apoptotic peptide of 24 amino acids; an identical open reading frame exists in the mitochondrial genome, and the mitochondrial version also binds and suppresses the cell-death protein Bax.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Humanin is an anti-apoptotic peptide of 24 amino acids; an identical open reading frame exists in the mitochondrial genome, and the mitochondrial version also binds and suppresses the cell-death protein Bax. · pmid:12732850
Classification
It is described as the first small peptide of a putative set of mitochondrial-derived peptides, with strong cytoprotective actions in stress and disease models. · pmid:23402768
Mechanism
It prevents Bax from moving from the cytosol to mitochondria and suppresses cytochrome c release. · pmid:12732850
Proportion of the 2 claims about Humanin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Humanin yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Humanin peptide suppresses apoptosis by interfering with Bax activation. · pmid 12732850 · 2003
Humanin: a harbinger of mitochondrial-derived peptides? · pmid 23402768 · 2013
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.