Peptide Atlas · Excipient

L-Histidine

Histidine is a widely used buffer in antibody formulations; under fluorescent light, histidine-derived photosensitizers accumulated in the buffer and mediated photo-oxidation of a monoclonal antibody.

preclinical

provisional
PubChem 6274
1 citation
0 discussions
0 followers
Histidine (free base)

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 1 citation resolves to their original source. · 0 posts naming it, 0 members counted once each.

created page created as 'L-Histidine' with aliases Histidine (free base) · 2026-09-27 04:00 · somebody
kind set kind set to excipient: palette r1 · 2026-09-27 04:00 · somebody
fact added identity: PubChem CID 6274: L-Histidine, C6H9N3O2, 155.15 g/mol. · 2026-09-27 04:00 · somebody
fact added identity: CAS registry number 71-00-1. · 2026-09-27 04:00 · somebody
fact added identity: IUPAC name: (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid. · 2026-09-27 04:00 · somebody
fact added summary: Histidine is a widely used buffer in antibody formulations; under fluorescent light, histidine-derived photosensitizers · 2026-09-27 04:00 · somebody
citation added pmid 21786276 cited as preclinical: Photosensitizers form in histidine buffer and mediate antibody photodegradation · 2026-09-27 04:00 · somebody

Negative findings

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