L-Histidine

Summary

Histidine is a widely used buffer in antibody formulations; under fluorescent light, histidine-derived photosensitizers accumulated in the buffer and mediated photo-oxidation of a monoclonal antibody. · pmid:21786276

Identity

PubChem CID 6274: L-Histidine, C6H9N3O2, 155.15 g/mol. · pubchem:6274

CAS registry number 71-00-1. · pubchem:6274

IUPAC name: (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid. · pubchem:6274

Where the evidence actually sits

Proportion of the 1 claim about L-Histidine standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for L-Histidine yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • Photosensitizers form in histidine buffer and mediate the photodegradation of a monoclonal antibody. · pmid 21786276 · 2011

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.