Peptide Atlas · Excipient

L-Histidine

Histidine is a widely used buffer in antibody formulations; under fluorescent light, histidine-derived photosensitizers accumulated in the buffer and mediated photo-oxidation of a monoclonal antibody.

preclinical

provisional
PubChem 6274
1 citation
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Histidine (free base)

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

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- preclinical
  Claim: Photosensitizers form in histidine buffer and mediate antibody photodegradation standing
- resolved
Photosensitizers form in histidine buffer and mediate the photodegradation of a monoclonal antibody.
Stroop SD, Conca DM, Lundgard RP, Renz ME, Peabody LM, Leigh SD
pmid 21786276

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Negative findings

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