Peptide Atlas · Excipient

L-Histidine

Histidine is a widely used buffer in antibody formulations; under fluorescent light, histidine-derived photosensitizers accumulated in the buffer and mediated photo-oxidation of a monoclonal antibody.

preclinical

provisional
PubChem 6274
1 citation
0 discussions
0 followers
Histidine (free base)

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 1 citation resolves to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for L-Histidine. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Photosensitizers form in histidine buffer and mediate antibody photodegradation	preclinical	pmid 21786276

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.