L-Proline

Summary

Proline, an osmolyte, prevented aggregation during the refolding of lysozyme where other osmolytes tested did not, apparently by trapping folding intermediates in aggregation-insensitive states. · pmid:10716186

Identity

PubChem CID 145742: L-Proline, C5H9NO2, 115.13 g/mol. · pubchem:145742

CAS registry number 147-85-3. · pubchem:145742

IUPAC name: (2S)-pyrrolidine-2-carboxylic acid. · pubchem:145742

Where the evidence actually sits

Proportion of the 1 claim about L-Proline standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for L-Proline yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • Proline inhibits aggregation during protein refolding. · pmid 10716186 · 2000

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.