Peptide Atlas · Peptide

PE-22-28

PE 22-28 is a 7-amino-acid peptide designed from the degradation products of spadin, a sortilin-derived peptide that blocks the TREK-1 potassium channel; it blocked human TREK-1 far more potently than spadin (IC50 0.12 nM against 40-60 nM).

preclinical

provisional
PubChem 165437303
1 citation
0 discussions
0 followers
GVSWGLR
TREK-1 antagonist peptide
spadin analog

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 1 citation resolves to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for PE-22-28. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Shortened spadin analog PE 22-28: potent TREK-1 inhibition and antidepressant activity in mice	preclinical	pmid 28955242

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.