Peptide Atlas · Peptide

PE-22-28

PE 22-28 is a 7-amino-acid peptide designed from the degradation products of spadin, a sortilin-derived peptide that blocks the TREK-1 potassium channel; it blocked human TREK-1 far more potently than spadin (IC50 0.12 nM against 40-60 nM).

preclinical

provisional
PubChem 165437303
1 citation
0 discussions
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GVSWGLR
TREK-1 antagonist peptide
spadin analog

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 1 citation resolves to their original source. · 0 posts naming it, 0 members counted once each.

- preclinical
  Claim: Shortened spadin analog PE 22-28: potent TREK-1 inhibition and antidepressant activity in mice standing
- resolved
Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity.
Djillani A, Pietri M, Moreno S, Heurteaux C, Mazella J, Borsotto M
pmid 28955242

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Negative findings

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