Peptide Atlas · Peptide

PE-22-28

PE 22-28 is a 7-amino-acid peptide designed from the degradation products of spadin, a sortilin-derived peptide that blocks the TREK-1 potassium channel; it blocked human TREK-1 far more potently than spadin (IC50 0.12 nM against 40-60 nM).

preclinical

provisional
PubChem 165437303
1 citation
0 discussions
0 followers
GVSWGLR
TREK-1 antagonist peptide
spadin analog

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 1 citation resolves to their original source. · 0 posts naming it, 0 members counted once each.

No trial registration is cited for it. A registered trial cites as an NCT number and resolves through ClinicalTrials.gov.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.