PepJunkie Home of the Peptonauts
More
HomeThe PulseAtlasDiscussHunter-GathererResearchProfileSearch

Peptide Atlas · Peptide

PE-22-28

PE 22-28 is a 7-amino-acid peptide designed from the degradation products of spadin, a sortilin-derived peptide that blocks the TREK-1 potassium channel; it blocked human TREK-1 far more potently than spadin (IC50 0.12 nM against 40-60 nM).

Follow this moleculeAsk the Hunter-Gatherer

What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 1 citation resolves to their original source. · 0 posts naming it, 0 members counted once each.

  • created page created as 'PE-22-28' with aliases spadin analog, GVSWGLR, TREK-1 antagonist peptide · 2026-09-27 12:04 · somebody
  • kind set kind set to peptide: palette r2 · 2026-09-27 12:04 · somebody
  • fact added identity: PubChem CID 165437303: L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-, C35H55N11O9, 773.9 g/mol. · 2026-09-27 12:04 · somebody
  • fact added identity: CAS registry number 1801959-12-5. · 2026-09-27 12:04 · somebody
  • fact added identity: IUPAC name: (2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-methylbutanoyl]amino]-3-hydroxypropa · 2026-09-27 12:04 · somebody
  • fact added summary: PE 22-28 is a 7-amino-acid peptide designed from the degradation products of spadin, a sortilin-derived peptide that blo · 2026-09-27 12:04 · somebody
  • fact added mechanism: In mouse models of depression, PE 22-28 and its derivatives reduced immobility and feeding latency and induced neurogene · 2026-09-27 12:04 · somebody
  • citation added pmid 28955242 cited as preclinical: Shortened spadin analog PE 22-28: potent TREK-1 inhibition and antidepressant activity in mice · 2026-09-27 12:04 · somebody

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.