Peptide Atlas · Peptide

PE-22-28

PE 22-28 is a 7-amino-acid peptide designed from the degradation products of spadin, a sortilin-derived peptide that blocks the TREK-1 potassium channel; it blocked human TREK-1 far more potently than spadin (IC50 0.12 nM against 40-60 nM).

preclinical

provisional
PubChem 165437303
1 citation
0 discussions
0 followers
GVSWGLR
TREK-1 antagonist peptide
spadin analog

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 1 citation resolves to their original source. · 0 posts naming it, 0 members counted once each.

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.