Peptide Atlas · Excipient

Trehalose

Trehalose is a disaccharide stabilizer; compared with sucrose it is more strongly excluded from proteins in solution, but more prone to phase separation and crystallization in frozen solutions, and it is hygroscopic.

established

provisional
PubChem 181978
2 citations
0 discussions
0 followers
Trehalose dihydrate

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

created page created as 'Trehalose' with aliases Trehalose dihydrate · 2026-09-27 04:00 · somebody
kind set kind set to excipient: palette r1 · 2026-09-27 04:00 · somebody
fact added identity: PubChem CID 181978: Trehalose, dihydrate, C12H26O13, 378.33 g/mol. · 2026-09-27 04:00 · somebody
fact added identity: CAS registry number 6138-23-4. · 2026-09-27 04:00 · somebody
fact added identity: IUPAC name: (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane- · 2026-09-27 04:00 · somebody
fact added summary: Trehalose is a disaccharide stabilizer; compared with sucrose it is more strongly excluded from proteins in solution, bu · 2026-09-27 04:00 · somebody
fact added mechanism: Its stabilization of ribonuclease A could be fully accounted for by the change in transfer free energy on unfolding. · 2026-09-27 04:00 · somebody
citation added pmid 37918545 cited as established: Review: sucrose, trehalose, cyclodextrins and dextrans in protein formulations · 2026-09-27 04:00 · somebody
citation added pmid 9127936 cited as preclinical: The thermodynamic mechanism of protein stabilization by trehalose · 2026-09-27 04:00 · somebody

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