Trehalose

Summary

Trehalose is a disaccharide stabilizer; compared with sucrose it is more strongly excluded from proteins in solution, but more prone to phase separation and crystallization in frozen solutions, and it is hygroscopic. · pmid:37918545

Mechanism

Its stabilization of ribonuclease A could be fully accounted for by the change in transfer free energy on unfolding. · pmid:9127936

Identity

PubChem CID 181978: Trehalose, dihydrate, C12H26O13, 378.33 g/mol. · pubchem:181978

CAS registry number 6138-23-4. · pubchem:181978

IUPAC name: (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol;dihydrate. · pubchem:181978

Where the evidence actually sits

Proportion of the 2 claims about Trehalose standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Trehalose yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier
   • Stabilization effects of saccharides in protein formulations: A review of sucrose, trehalose, cyclodextrins and dextrans. · pmid 37918545 · 2024
3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • The thermodynamic mechanism of protein stabilization by trehalose. · pmid 9127936 · 1997

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.