Peptide Atlas · Excipient

Trehalose

Trehalose is a disaccharide stabilizer; compared with sucrose it is more strongly excluded from proteins in solution, but more prone to phase separation and crystallization in frozen solutions, and it is hygroscopic.

established

provisional
PubChem 181978
2 citations
0 discussions
0 followers
Trehalose dihydrate

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- established
  Claim: Review: sucrose, trehalose, cyclodextrins and dextrans in protein formulations standing
- resolved
Stabilization effects of saccharides in protein formulations: A review of sucrose, trehalose, cyclodextrins and dextrans.
Li J, Wang H, Wang L, Yu D, Zhang X
pmid 37918545
- preclinical
  Claim: The thermodynamic mechanism of protein stabilization by trehalose standing
- resolved
The thermodynamic mechanism of protein stabilization by trehalose.
Xie G, Timasheff SN
pmid 9127936

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

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