Peptide Atlas · Excipient

Trehalose

Trehalose is a disaccharide stabilizer; compared with sucrose it is more strongly excluded from proteins in solution, but more prone to phase separation and crystallization in frozen solutions, and it is hygroscopic.

established

provisional
PubChem 181978
2 citations
0 discussions
0 followers
Trehalose dihydrate

Follow this molecule Ask the Hunter-Gatherer

What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Trehalose. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Review: sucrose, trehalose, cyclodextrins and dextrans in protein formulations	established	pmid 37918545
The thermodynamic mechanism of protein stabilization by trehalose	preclinical	pmid 9127936

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.