Peptide Atlas · Peptide

Orexin B

Orexin B (hypocretin-2) is one of two hypothalamic orexin peptides; the orexin system is a critical regulator of sleep and wakefulness, and deficient orexin signaling causes narcolepsy-cataplexy in humans, dogs and rodents.

established

provisional
PubChem 90479794
3 citations
0 discussions
0 followers
Hypocretin-2

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Orexin B. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Review: the orexin system regulates sleep and wakefulness; its deficiency causes narcolepsy	established	pmid 19689310
Orexin A, but not orexin B, enters the brain from blood in mice	preclinical	pmid 10087007
Distribution of orexin-A and orexin-B immunoreactivity in rat brain and spinal cord	preclinical	pmid 10698122

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.