Orexin B (hypocretin-2) is one of two hypothalamic orexin peptides; the orexin system is a critical regulator of sleep and wakefulness, and deficient orexin signaling causes narcolepsy-cataplexy in humans, dogs and rodents.
fact added identity: CAS registry number 205640-91-1. · 2026-09-27 12:04 · somebody
fact added summary: Orexin B (hypocretin-2) is one of two hypothalamic orexin peptides; the orexin system is a critical regulator of sleep a · 2026-09-27 12:04 · somebody
fact added summary: In rats, orexin-A and orexin-B cell bodies lie only in the lateral hypothalamus and perifornical nuclei, but orexin-B fi · 2026-09-27 12:04 · somebody
fact added mechanism: In mice, orexin A crossed the blood-brain barrier from the blood by simple diffusion, whereas orexin B was rapidly degra · 2026-09-27 12:04 · somebody
citation added pmid 19689310 cited as established: Review: the orexin system regulates sleep and wakefulness; its deficiency causes narcolepsy · 2026-09-27 12:04 · somebody
citation added pmid 10698122 cited as preclinical: Distribution of orexin-A and orexin-B immunoreactivity in rat brain and spinal cord · 2026-09-27 12:04 · somebody
citation added pmid 10087007 cited as preclinical: Orexin A, but not orexin B, enters the brain from blood in mice · 2026-09-27 12:04 · somebody
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.