Peptide Atlas · Peptide

Orexin B

Orexin B (hypocretin-2) is one of two hypothalamic orexin peptides; the orexin system is a critical regulator of sleep and wakefulness, and deficient orexin signaling causes narcolepsy-cataplexy in humans, dogs and rodents.

established

provisional
PubChem 90479794
3 citations
0 discussions
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Hypocretin-2

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- established
  Claim: Review: the orexin system regulates sleep and wakefulness; its deficiency causes narcolepsy standing
- resolved
Integrative physiology of orexins and orexin receptors.
Mieda M, Sakurai T
pmid 19689310
- preclinical
  Claim: Orexin A, but not orexin B, enters the brain from blood in mice standing
- resolved
Orexin A but not orexin B rapidly enters brain from blood by simple diffusion.
Kastin AJ, Akerstrom V
pmid 10087007
- preclinical
  Claim: Distribution of orexin-A and orexin-B immunoreactivity in rat brain and spinal cord standing
- resolved
Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord.
Cutler DJ, Morris R, Sheridhar V, Wattam TA, Holmes S, Patel S, Arch JR, Wilson S, Buckingham RE, Evans ML, Leslie RA, Williams G
pmid 10698122

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